| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Microbiology, University of Aberdeen, Marischal College, Aberdeen AB9 1AS, U.K.
ABSTRACT
Summary: The growth and development of mycelia of the dimorphic fungus Candida albicans in serumcontaining medium is described. Initially, colonies are undifferentiated (all hyphae in the mycelium having approximately the same diameter, extension rate, apical and intercalary compartment lengths) whereas older mycelia differentiate at the colony margin to produce leading hyphae that are wider, faster growing and have longer apical and intercalary compartment lengths than the branches they subtend. Early colony development exhibits unusual features: germ tube extension is linear (not exponential as in other fungi) and there is a prolonged delay between septation and the onset of branch formation. The subsequent patterns of growth and branching are similar in all other respects to those of other mycelial moulds. Mycelia have septa that delimit single nuclei within compartments. The septa do not prevent cytoplasmic flow and consequently allow the peripheral growth zone to span several compartments. From these results we conclude that filamentous growth of C. albicans in this medium is best described as truly mycelial.
This article has been cited by other articles:
|
|
 |
|
  S. D. Harris Branching of fungal hyphae: regulation, mechanisms and comparison with other branching systems. Mycologia, November 1, 2008; 100(6): 823 - 832. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Enjalbert, D. M. MacCallum, F. C. Odds, and A. J. P. Brown Niche-Specific Activation of the Oxidative Stress Response by the Pathogenic Fungus Candida albicans Infect. Immun., May 1, 2007; 75(5): 2143 - 2151. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Eisman, R. Alonso-Monge, E. Roman, D. Arana, C. Nombela, and J. Pla The Cek1 and Hog1 Mitogen-Activated Protein Kinases Play Complementary Roles in Cell Wall Biogenesis and Chlamydospore Formation in the Fungal Pathogen Candida albicans Eukaryot. Cell, February 1, 2006; 5(2): 347 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Barelle, M. L. Richard, C. Gaillardin, N. A. R. Gow, and A. J. P. Brown Candida albicans VAC8 Is Required for Vacuolar Inheritance and Normal Hyphal Branching Eukaryot. Cell, February 1, 2006; 5(2): 359 - 367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sanz, L. Carrano, C. Jimenez, G. Candiani, J. A. Trilla, A. Duran, and C. Roncero Candida albicans strains deficient in CHS7, a key regulator of chitin synthase III, exhibit morphogenetic alterations and attenuated virulence Microbiology, August 1, 2005; 151(8): 2623 - 2636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Hausauer, M. Gerami-Nejad, C. Kistler-Anderson, and C. A. Gale Hyphal Guidance and Invasive Growth in Candida albicans Require the Ras-Like GTPase Rsr1p and Its GTPase-Activating Protein Bud2p Eukaryot. Cell, July 1, 2005; 4(7): 1273 - 1286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Munro, S. Bates, E. T. Buurman, H. B. Hughes, D. M. MacCallum, G. Bertram, A. Atrih, M. A. J. Ferguson, J. M. Bain, A. Brand, et al. Mnt1p and Mnt2p of Candida albicans Are Partially Redundant {alpha}-1,2-Mannosyltransferases That Participate in O-Linked Mannosylation and Are Required for Adhesion and Virulence J. Biol. Chem., January 14, 2005; 280(2): 1051 - 1060. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Selvaggini, C. A. Munro, S. Paschoud, D. Sanglard, and N. A. R. Gow Independent regulation of chitin synthase and chitinase activity in Candida albicans and Saccharomyces cerevisiae Microbiology, April 1, 2004; 150(4): 921 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Knechtle, F. Dietrich, and P. Philippsen Maximal Polar Growth Potential Depends on the Polarisome Component AgSpa2 in the Filamentous Fungus Ashbya gossypii Mol. Biol. Cell, October 1, 2003; 14(10): 4140 - 4154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Barelle, E. A. Bohula, S. J. Kron, D. Wessels, D. R. Soll, A. Schafer, A. J. P. Brown, and N. A. R. Gow Asynchronous Cell Cycle and Asymmetric Vacuolar Inheritance in True Hyphae of Candida albicans Eukaryot. Cell, June 1, 2003; 2(3): 398 - 410. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Felk, M. Kretschmar, A. Albrecht, M. Schaller, S. Beinhauer, T. Nichterlein, D. Sanglard, H. C. Korting, W. Schafer, and B. Hube Candida albicans Hyphal Formation and the Expression of the Efg1-Regulated Proteinases Sap4 to Sap6 Are Required for the Invasion of Parenchymal Organs Infect. Immun., July 1, 2002; 70(7): 3689 - 3700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Ayad-Durieux, P Knechtle, S Goff, F Dietrich, and P Philippsen A PAK-like protein kinase is required for maturation of young hyphae and septation in the filamentous ascomycete Ashbya gossypii J. Cell Sci., January 12, 2000; 113(24): 4563 - 4575. [Abstract] [PDF]
|
|
|
|
|
|
C. Csank, K. Schroppel, E. Leberer, D. Harcus, O. Mohamed, S. Meloche, D. Y. Thomas, and M. Whiteway Roles of the Candida albicans Mitogen-Activated Protein Kinase Homolog, Cek1p, in Hyphal Development and Systemic Candidiasis Infect. Immun., June 1, 1998; 66(6): 2713 - 2721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Csank, C. Makris, S. Meloche, K. Schröppel, M. Röllinghoff, D. Dignard, D. Y. Thomas, and M. Whiteway Derepressed Hyphal Growth and Reduced Virulence in a VH1 Family-related Protein Phosphatase Mutant of the Human Pathogen Candida albicans Mol. Biol. Cell, December 1, 1997; 8(12): 2539 - 2551. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
