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Nitrogen Fixation Laboratory, University of Sussex, Brighton BN1 9RQ, UK
John Innes Centre, Nitrogen Fixation Laboratory, Norwich Research Park, Colney, Norwich NR4 7UH, UK
3Author for correspondence: Richard N. Pau. Tel: +44 1603 456900. Fax: +44 1603 454970. e-mail: pau@bbsrc.ac.uk
ABSTRACT
The Azotobacter vinelandii mod locus, which is involved in high-affinity molybdate transport and the early events in Mo metabolism, consists of two divergently transcribed operons, modG and modEABC. modA, modB and modC encode the components of the high-affinity molybdate transporter, and modG encodes a Mo-binding protein. High concentrations of Mo repressed transcription of both operons. The modEABC operon was also repressed by tungstate and to a lesser extent by vanadate. modE, the first gene in the modEABC operon, controlled the Mo-dependent transcription of both operons. It was not involved in the metal regulation of alternative nitrogenase gene expression. Although a modE mutant constitutively expressed genes encoding the molybdate transporter, it had a reduced rate of Mo accumulation.
Present address: Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston MA 02115, USA.
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