| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Laboratory of Microbial Structure and Function, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
Microscopy Branch, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, Hamilton, MT 59840, USA
3Author for correspondence: Kit Tilly. Tel: +1 406 363 9239. Fax: +1 406 363 9204. e-mail: ktilly@nih.gov
ABSTRACT
Linear DNA with covalently closed ends is the predominant form of DNA in the spirochaete Borrelia burgdorferi. All bacteria examined to date have small DNA-binding proteins related to the Escherichia coli IHF and HU proteins that appear to play roles in DNA compaction and replication, but such proteins had not been isolated from bacteria with linear genomes. We found a single gene in B. burgdorferi (named hbb) whose product (named Hbb) complements the defects for 
DNA packaging found in E. coli strains mutant in the genes for IHF and HU. The sequence of the predicted B. burgdorferi protein is similar to those of HU and IHF-like proteins in other bacteria. The gene appears to be in an operon with the order rpsT-hbb-orfH, where the rpsT gene is a homologue of the E. coli gene encoding ribosomal protein S20 and the orfH gene encodes a protein of unknown function. This operon is located upstream of the previously identified B. burgdorferi rho homologue.
Present address: Division of Biological Sciences, University of Montana, Missoula, MT 59812, USA.
This article has been cited by other articles:
|
|
 |
|
  V. B. Mulay, M. J. Caimano, R. Iyer, S. Dunham-Ems, D. Liveris, M. M. Petzke, I. Schwartz, and J. D. Radolf Borrelia burgdorferi bba74 Is Expressed Exclusively during Tick Feeding and Is Regulated by Both Arthropod- and Mammalian Host-Specific Signals J. Bacteriol., April 15, 2009; 191(8): 2783 - 2794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Riley, T. Bykowski, A. E. Cooley, L. H. Burns, K. Babb, C. A. Brissette, A. Bowman, M. Rotondi, M. C. Miller, E. DeMoll, et al. Borrelia burgdorferi EbfC defines a newly-identified, widespread family of bacterial DNA-binding proteins Nucleic Acids Res., April 1, 2009; 37(6): 1973 - 1983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Eggers, M. J. Caimano, and J. D. Radolf Analysis of Promoter Elements Involved in the Transcriptional Initiation of RpoS-Dependent Borrelia burgdorferi Genes J. Bacteriol., November 1, 2004; 186(21): 7390 - 7402. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Liveris, V. Mulay, and I. Schwartz Functional Properties of Borrelia burgdorferi recA J. Bacteriol., April 15, 2004; 186(8): 2275 - 2280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. W. Knight, B. J. Kimmel, C. H. Eggers, and D. S. Samuels Disruption of the Borrelia burgdorferi gac Gene, Encoding the Naturally Synthesized GyrA C-Terminal Domain J. Bacteriol., April 1, 2000; 182(7): 2048 - 2051. [Abstract] [Full Text]
|
|
|
|
|
|
K. J. Indest and M. T. Philipp DNA-Binding Proteins Possibly Involved in Regulation of the Post-Logarithmic-Phase Expression of Lipoprotein P35 in Borrelia burgdorferi J. Bacteriol., January 15, 2000; 182(2): 522 - 525. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
