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bofC Encodes a Putative Forespore Regulator of the Bacillus Subtilis k Checkpoint

Manuel Gomez

Simon M. Cutting^1,

Department of Microbiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6076, USA

ABSTRACT

A mutation, bofC1, that restores ^K activation in Bacillus subtilis strains unable to produce active ^G has been identified. This mutation defines a new sporulation gene, bofC, that has been cloned and sequenced and encodes a 19 kDa protein. bofC is transcribed in the forespore by RNA polymerase associated with the transcription factors ^F (E^F) and ^G (E^G). BofC acts negatively on SpolVB and the results described suggest that BofC regulates SpolVB activity and its intercompartmental signalling role in the ^K checkpoint

¹Author for correspondence: Simon M. Cutting. Tel: +44 1784 443760. Fax: +44 1784 434326.

Present address: School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW2

Present address: Public Health Research Institute, 455 1st Avenue, New York, NY 10016, USA.

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