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Microbiology 143 (1997), 3757-3765; DOI  10.1099/00221287-143-12-3757
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Influence of Na+ and anions on the dimorphic transition of Candida albicans

Frederick D. Northrop1, Srdjan Ljubojevic2 and Julia M. Davies1

1 Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, UK
2 Department of Biology, University of York, PO Box 373, York YO1 5YW, UK

Author for correspondence: Julia.M. Davies. Tel: +44 1223 333 939. Fax: + 44 1223 333 953. e-mail: JMD32@cam.ac.uk

ABSTRACT

The effect of Na+ (CI- or gluconate salt) on growth and dimorphic potential of the pathogenic yeast Candida albicans has been examined. Profiles of germ tube formation as a function of salt addition, pH and temperature indicated Na+ inhibition of germ tube outgrowth at high ambient pH (pH 8.0) which was exacerbated by replacement of CI- with gluconate (as an impermeant analogue). At acidic pH (pH 5.5) and permissive temperature (37 °), gluconate alone promoted the dimorphic transition. Rates of glucose-induced medium acidification and plasma membrane H+-ATPase activity have been measured to assess whether salt treatments could retard the cytoplasmic alkalinization known to precede germ tube formation. The precise site of Na+ action remains unclear but the anion effects may be interpreted in terms of anion-exchanger and channel activity acting to modulate cytosolic pH.

Keywords: Na+, lithium, anions, Candida albicans, pH regulation




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