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Microbiology 143 (1997), 2079-2084; DOI  10.1099/00221287-143-6-2079
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Metabolic regulation of Irp gene expression in Escherichia coli K-12

C. F. Chen, J. Lan, M. Korovine, Z. Q. Shao, L. Tao, J. Zhang and E. B. Newman

Biology Department, Concordia University, 1455 de Maisonneuve Ave., Montreal, Quebec, Canada H3G 1M8

Author for correspondence: E. B. Newman. Tel: +1 514 848 3410. Fax: + 1 514 848 2881. e-mail: neweb@vax2.concordia.ca

ABSTRACT

Expression of the Irp gene is regulated in part by the nutrients available to the cell, and is decreased in rich medium, in glucose minimal media enriched with amino acids, and in minimal medium with alternative carbon sources, such as acetate and succinate. When Lrp production is increased in a given medium, expression of its target genes is also increased. However, when the medium is changed from glucose to acetate, the response of the target genes is governed by many factors.

Keywords: Escherichia coli, leucine-responsive regulatory protein, regulation of lrp expression, metabolism




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