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University of Maryland, Baltimore County, Program in Molecular and Cell Biology, Baltimore, MD 21228, USA
Laboratory of Microbiology, Rockefeller University, New York, NY 10021, USA
Department of Microbiology, Molecular Biology and Biochemistry, University of Idaho, Moscow, ID 83844-3052, USA
Author for correspondence: Kenneth W. Bayles. Tel: +1 208 885 7966. Fax: +1 208 885 6518. e-mail: kbayles@uidaho.edu
ABSTRACT
Summary: A new Staphylococcus aureus gene termed scdA was found upstream of the autolysis regulatory genes, lytS and lytR, and was shown to potentially encode a hydrophilic 25 kDa protein. Analysis of scdA transcription revealed that it is transcribed as a monocistronic message and is lytSR-independent. A role in cell wall metabolism was indicated by examination of the scdA mutant S. aureus KB323, which had a grossly aberrant cellular morphology and formed large cell clusters when grown in liquid culture medium. Furthermore, KB323 exhibited a reduced rate of autolysis and had increased peptidoglycan cross-linking compared to the parental strain, NCTC 8325-4. These data suggest that scdA plays an important role in staphylococcal cell division.
Present address: The Children's Hospital Research Foundation, Department of Developmental Biology, 3333 Burnet Ave, Cincinnati, OH 45229-3039, USA.
Present address: Astra Research Center Boston, Inc., 128 Sidney St, Cambridge, MA 02139-4239, USA.
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