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microbiology, Vol 144, 193-199, Copyright © 1998 by Society for General Microbiology
ARTICLES |
PP Chong, SM Podmore, HM Kieser, M Redenbach, K Turgay, M Marahiel, DA Hopwood and CP Smith
Department of Biochemistry and Applied Molecular Biology, University of Manchester Institute of Science and Technology (UMIST), UK.
Putative peptide-synthetase-encoding DNA fragments were isolated from the Streptomyces coelicolor A3(2) chromosome using a PCR-based approach and mapped to a single approximately 35 kb segment. In integrative transformation experiments, DNA fragments from this region disrupted production of the calcium-dependent antibiotic (CDA) and had sequences characteristic of non-ribosomal peptide synthetases, thus proving that the cda locus had been cloned.
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