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1 Dipartimento di Genetica e Microbiologia, Università di Pavia, via Abbiategrasso, 207, 27100 Pavia, Italy
2 Dipartimento di Biochimica, Università di Pavia, via Bassi, 21, 27100 Pavia, Italy
ABSTRACT
A 15437 bp region encompassing the inhA locus from the Mycobacterium avium chromosome was cloned and sequenced. From the sequencing data generated and the results of homology searches, the primary structure of this region was determined. This region contains four known genes (acnA, fabG, inhA and hemH) and two genes, invA and invB, whose products display homology with p60 invasion protein of Listeria monocytogenes. Six proteins encoded by putative ORFs contained an RGD motif (often involved in binding to macrophage integrins), while ORF1 and MoxR are probably transcriptional regulators. The rest of the putative products encoded by ORFs in the sequenced region showed little homology with the proteins contained in the databases and were considered to be unknown proteins.
Author for correspondence: Giovanna Riccardi. Tel: + 39 382 505 574. Fax: +39 382 528 496. e-mail: riccardi@ipvgen.unipv.it
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