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Staphylococcus aureus expresses a cell surface protein that binds both IgG and β₂-glycoprotein I

Katrin Ström

Department of Microbiology, Swedish University of Agricultural Sciences, SE-750 07 Uppsala, Sweden

Author for correspondence: Lars Frykberg. Tel: +46 18 67 32 99. Fax: +46 18 67 33 92. e-mail: Lars.Frykberg@mikrob.slu.se

ABSTRACT

Summary: The existence of a second IgG-binding protein, protein Sbi, in Staphylococcus aureus has been reported previously. Later data indicated that protein Sbi also bound another serum component. This component has now been affinity-purified on immobilized protein Sbi and identified as β₂-glycoprotein I (β₂-GPI), also known as apolipoprotein H. The minimal β₂-GPI-binding domain was identified by shotgun phage display and the binding was shown to be mediated by a region of 57 amino acids, clearly separated from the IgG-binding domain. It is also shown that protein Sbi, and thus the β₂-GPI-binding activity, is expressed on the staphylococcal cell surface at levels varying between strains.

Present address: Department of Pharmaceutical Biosciences, Uppsala University, Box 581, SE-751 23 Uppsala, Sweden.

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