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Catalase activity is necessary for heat-shock recovery in Aspergillus nidulans germlings

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo and Universidade de Franca, Av. do Café S/N, CEP 14040-903, Ribeirão Preto, São Paulo, Brazil¹
Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil²
Instituto de Fisiologia Celular-UNAM, Mexico City, Mexico³
Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID, USA⁴

Author for correspondence: Gustavo H. Goldman. Tel: +55 16 6024280/81. Fax: +55 16 6331092/6024280. e-mail: ggoldman{at}usp.br

To understand the molecular mechanisms induced by stress that contribute to the development of tolerance in eukaryotic cells, the filamentous fungus Aspergillus nidulans has been chosen as a model system. Here, the response of A. nidulans germlings to heat shock is reported. The heat treatment dramatically increased the concentration of trehalose and induced the accumulation of mannitol and mRNA from the catalase gene catA. Both mannitol and catalase function to protect cells from different reactive oxygen species. Treatment with hydrogen peroxide increased A. nidulans germling viability after heat shock whilst mutants deficient in catalase were more sensitive to a 50 °C heat exposure. It is concluded that the defence against the lethal effects of heat exposure can be correlated with the activity of the defence system against oxidative stress.

Keywords: catalase, heat shock, stress tolerance, Aspergillus nidulans

Abbreviations: ROS, reactive oxygen species

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