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Oocydin A, a chlorinated macrocyclic lactone with potent anti- oomycete activity from Serratia marcescens

Department of Plant Sciences, Montana State University, Bozeman, MT 59717, USA¹
Department of Applied Biological Science, Science University of Tokyo, Noda, Chiba 278-8510, Japan²
The Institute of Physical and Chemical Research, Wako, Saitama 351- 0198, Tokyo, Japan³
Department of Chemistry, University of Utah, Salt Lake City, UT 84112, USA⁴
Department of Botany and Range Science, Brigham Young University, Provo, UT 84602, USA⁵

Author for correspondence: Gary Strobel. Tel: +1 406 994 5148. Fax: +1 406 994 7600. e-mail: uplgs{at}montana.edu

A unique chlorinated macrocyclic lactone, termed oocydin A, was isolated from a strain of Serratia marcescens growing as an epiphyte on Rhyncholacis pedicillata, an aquatic plant native to the Carrao river of the Venezuelan-Guyanan region of South America. The lactone has a molecular mass of 470 Da, and contains one atom of chlorine, a carboxyl group and a tetrahydrofuran ring internal to a larger macrocyclic ring. MICs of approximately 0·03 µg ml^-1 were noted for oocydin A against such phytopathogenic oomycetes as Pythium ultimum, Phytophthora parasitica, Phytophthora cinnamomi and Phytophthora citrophora. With regard to the true fungi, oocydin A had either minimal or no effect against certain Fungi Imperfecti (including several pathogens of humans), two ascomycetes and a basidiomycete. Oocydin A may have potential as an antimycotic in agricultural applications and especially for crop protection.

Keywords: antimycotic, phycomycetes, aquatic ecology , epiphyte

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