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Microbiology 145 (1999), 1919-1926; DOI  10.1099/13500872-145-8-1919
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Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina

Gary A. Strobel1, R. Vincent Miller1, Concepcion Martinez-Miller1, Margaret M. Condron2, David B. Teplow2 and W. M. Hess3

1 Department of Plant Sciences, Montana State University, Bozeman, MT 59717, USA
2 Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
3 Department of Botany and Range Science, Brigham Young University, Provo, UT 84601, USA

Author for correspondence: Gary A. Strobel. Tel: + 1 406 994 5148. Fax: + 1 406 994 1848. e-mail: uplgs@montana.edu

ABSTRACT

A unique lipopeptide antimycotic, termed cryptocandin, is described from Cryptosporiopsis cf. quercina, an endophytic fungus. Cryptocandin, with a molecular mass of 1079 Da, contains equimolar amounts of 3,4-dihydroxyhomotyrosine, 4-hydroxyproline, threonine, glutamine, 3-hydroxy-4-hydroxymethylproline, 4,5-dihydroxyornithine and palmitic acid. Cryptocandin is chemically related to well-known antimycotics, the echinocandins and pneumocandins, which are produced by such fungi as Zalerion arboricola, Pezicula spp. and Aspergillus spp. Cryptocandin has minimal inhibitory concentration values of 0-03-0-07 µg ml-1 against isolates of Candida albicans, Trichophyton mentagrophytes and Trichophyton rubrum. Cryptocandin is also active against a number of plant-pathogenic fungi including Sclerotinia sclerotiorum and Botrytis cinerea.

Keywords: Trichophyton, endophyte, lipopeptide, 4,4-dimethoxytrityl chloride

Abbreviation: DMT, 4,4-dimethoxytrityl chloride.




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