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Microbiology 146 (2000), 949-955
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Microbiology (2000), 146, 949-955.
© 2000 Society for General Microbiology

Development and Structure

Lactococcin 972, a bacteriocin that inhibits septum formation in lactococci

Beatriz Martínez1, Ana Rodríguez1 and Juan E. Suárez1,2

Instituto de Productos Lácteos de Asturias (IPLA-CSIC), 33300-Villaviciosa, Asturias, Spain1
Departamento de Biología Funcional, Area de Microbiología, Universidad de Oviedo, 33006-Oviedo, Asturias, Spain2

Author for correspondence: Juan E. Suárez. Tel: +34 98 510 35 59. Fax: +34 98 510 31 48. e-mail: jsuarez{at}sauron.quimica.uniovi.es

Addition of lactococcin 972 to exponentially growing sensitive cultures of Lactococcus lactis resulted in cell elongation and widening. Thin sections revealed that septum invagination was blocked. Cell growth progressed until most cells showed equatorial constriction and even initial deposition of material at the septum ring, although cell division did not proceed any further. The increase in the incorporation of labelled precursors into the cell wall shifted from an exponential to a linear mode in treated cultures, subsequently being arrested. Gross degeneration of the cells was observed prior to cell death, followed by slow lysis of the culture. In contrast, stationary-phase cultures remained unaffected.

Keywords: lactococcin 972, septum biosynthesis, bacteriocin, Lactococcus lactis




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