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Porins from Salmonella enterica serovar Typhimurium induce TNF-, IL-6 and IL-8 release by CD14-independent and CD11a/CD18-dependent mechanisms

Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Larghetto S. Aniello a Caponapoli n 2, 80138 Naples, Italy¹

Author for correspondence: Marilena Galdiero. Tel: +39 081 5665662. Fax: +39 081 5665663. e-mail: marilena.galdiero{at}unina2.it

Lipopolysaccharide (LPS) of Gram-negative bacteria and several surface components of Gram-positive bacteria utilize CD14 and CD11a/18 as cellular receptors to induce expression and release of cytokines. Of the surface components of Gram-negative bacteria, porins exhibit a biological activity similar to that of LPS. The results in this paper show that the mechanism of stimulation by porins of THP-1 cells enriched in CD14 receptor after treatment with 1,25-dihydroxyvitamin D₃ (vitamin D₃) is independent of this receptor, but is partially dependent on CD11a/18 integrins.

Keywords: Salmonella typhimurium, lipopolysaccharide, cytokines, integrins, cellular receptors

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