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Molecular Genetics and Immunobiology of Mycobacteria |
Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Rua do Campo Alegre, 823,4150-180 Porto, Portugal1
Author for correspondence: M. Salomé Gomes. Tel: +351 226074900. Fax: +351 226099157. e-mail: sgomes{at}ibmc.up.pt
Restriction of the growth of Mycobacterium avium was studied in wild-type and p47phox-deficient macrophages. The ability of gamma interferon and tumour necrosis factor alpha to induce antimycobacterial activity in bone-marrow-derived macrophages or the expression of the NRAMP1-mediated resistance to M. avium were not affected by the deficiency in p47phox. The addition of exogenous iron increased mycobacterial growth in macrophages expressing a functional NRAMP1 protein or a mutant NRAMP1 protein. Reactive oxygen species are therefore not involved in the constitutive or induced anti-M. avium activities of the mouse macrophage.
Keywords: iron, antimicrobial, innate immunity
Abbreviations: BMM
, bone-marrow-derived macrophages; IFN-
, gamma interferon; SmD, smooth domed; SmT, smooth transparent; TNF-
, tumour necrosis factor
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