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Microbiology 148 (2002), 3609-3615
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Microbiology (2002), 148, 3609-3615.
© 2002 Society for General Microbiology

Research Paper

The role of multiple SOS boxes upstream of the Mycobacterium tuberculosis lexA gene – identification of a novel DNA-damage-inducible gene

Edith M. Dullaghana,1, Patricia C. Brooks1 and Elaine O. Davis1

Division of Mycobacterial Research, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK1

Author for correspondence: Elaine O. Davis. Tel: +44 20 8959 3666. Fax: +44 20 8913 8528. e-mail: edavis{at}nimr.mrc.ac.uk

Four potential binding sites for LexA were identified upstream of the Mycobacterium tuberculosis lexA gene. A mutational analysis of these sites in a lexA–lacZ reporter construct revealed that only one of these SOS boxes was required for DNA-damage-mediated regulation of lexA expression. A novel DNA-damage-inducible gene, Rv2719c, was identified that was divergently transcribed relative to lexA; the other three SOS boxes were found to be involved in regulating expression of this novel mycobacterial-specific gene. The SOS boxes lay in the respective promoter regions of the genes that they regulated.

Keywords: LexA, SOS box, mycobacteria

Abbreviations: RACE, rapid amplification of cDNA ends

a Present address: The University of British Columbia, The Research Centre, Faculty of Medicine, Dept of Paediatrics, 950 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4.




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