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Microbiology 148 (2002), 773-782
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Microbiology (2002), 148, 773-782.
© 2002 Society for General Microbiology

Research Paper

Detection and mutation of a luxS-encoded autoinducer in Proteus mirabilis

Rachel Schneider1, C. Virginia Lockatell2,3, David Johnson2,3 and Robert Belas1

Center of Marine Biotechnology, University of Maryland Biotechnology Institute, 701 East Pratt Street, Baltimore, MD 21202, USA1
University of Maryland School of Medicine2 and Research Service3, Veterans Administration Medical Center, Baltimore, MD 21201, USA

Author for correspondence: Robert Belas. Tel: +1 410 234 8876. Fax: +1 410 234 8896. e-mail: belas{at}umbi.umd.edu

Quorum sensing regulates the expression of virulence factors in a wide variety of pathogenic bacteria. This study has shown that Proteus mirabilis harbours a homologue of luxS, a gene required for the synthesis of the quorum sensing autoinducer 2 (AI-2). AI-2 activity is expressed during and is correlated with the initiation of swarming migration on agar surfaces. The P. mirabilis luxS locus was cloned and a LuxS- strain constructed by allelic-exchange mutagenesis. While lacking AI-2 activity, a null mutation in luxS, however, did not affect swimming or swarming motility, swarmer cell differentiation, or virulence in a mouse model of ascending urinary tract infection.

Keywords: quorum sensing, LuxS, swarming, virulence, urinary tract infection

Abbreviations: AHL, N-acylhomoserine lactone; AI, autoinducer; UTI, urinary tract infection

The GenBank accession number for the sequence reported in this paper is AY044337.




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