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Institut für Mikrobiologie und Molekularbiologie, University of Giessen, Heinrich-Buff-Ring 26-32, D-35392 Giessen, Germany
Correspondence
Gabriele Klug
gabriele.klug{at}mikro.bio.uni-giessen.de
Thioredoxins are small ubiquitous proteins that display different functions mainly via redox-mediated processes. The facultatively photosynthetic bacterium Rhodobacter capsulatus harbours at least two genes for thioredoxin 1 and 2, trxA and trxC. It is demonstrated that thioredoxin 2 of R. capsulatus can partially replace the thioredoxin 1 function as a hydrogen donor for methionine sulfoxide reductase but cannot replace thioredoxin 1 as a subunit of phage T7 DNA polymerase. By inactivating the trxC gene in R. capsulatus, it is shown that thioredoxin 2 is involved in resistance against oxidative stress. As thioredoxin 1 of Rhodobacter sphaeroides, R. capsulatus thioredoxin 2 affects the oxygen-dependent expression of photosynthesis genes, albeit in an opposite way. The trxC mutant of R. capsulatus shows a stronger increase in photosynthesis gene expression after a decrease in oxygen tension than the isogenic wild-type strain. The expression of the trxC gene is downregulated by oxygen.
Present address: Institut für Mikrobiologie, TU Braunschweig, Spielmannstr. 7, 38106 Braunschweig, Germany.
This article has been cited by other articles:
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 T. Zeller, M. A. Mraheil, O. V. Moskvin, K. Li, M. Gomelsky, and G. Klug Regulation of Hydrogen Peroxide-Dependent Gene Expression in Rhodobacter sphaeroides: Regulatory Functions of OxyR J. Bacteriol., May 15, 2007; 189(10): 3784 - 3792. [Abstract] [Full Text] [PDF]
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T. Zeller, K. Li, and G. Klug Expression of the trxC Gene of Rhodobacter capsulatus: Response to Cellular Redox Status Is Mediated by the Transcriptional Regulator OxyR J. Bacteriol., November 1, 2006; 188(21): 7689 - 7695. [Abstract] [Full Text] [PDF]
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T. Zeller, O. V. Moskvin, K. Li, G. Klug, and M. Gomelsky Transcriptome and Physiological Responses to Hydrogen Peroxide of the Facultatively Phototrophic Bacterium Rhodobacter sphaeroides J. Bacteriol., November 1, 2005; 187(21): 7232 - 7242. [Abstract] [Full Text] [PDF]
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 J. Glaeser and G. Klug Photo-oxidative stress in Rhodobacter sphaeroides: protective role of carotenoids and expression of selected genes Microbiology, June 1, 2005; 151(6): 1927 - 1938. [Abstract] [Full Text] [PDF]
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K. Li, S. Hein, W. Zou, and G. Klug The Glutathione-Glutaredoxin System in Rhodobacter capsulatus: Part of a Complex Regulatory Network Controlling Defense against Oxidative Stress J. Bacteriol., October 15, 2004; 186(20): 6800 - 6808. [Abstract] [Full Text] [PDF]
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T. Zeller and G. Klug Detoxification of hydrogen peroxide and expression of catalase genes in Rhodobacter Microbiology, October 1, 2004; 150(10): 3451 - 3462. [Abstract] [Full Text] [PDF]
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 K. Li, C. Pasternak, E. Hartig, K. Haberzettl, A. Maxwell, and G. Klug Thioredoxin can influence gene expression by affecting gyrase activity Nucleic Acids Res., August 24, 2004; 32(15): 4563 - 4575. [Abstract] [Full Text] [PDF]
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 Y. Han, S. Braatsch, L. Osterloh, and G. Klug A eukaryotic BLUF domain mediates light-dependent gene expression in the purple bacterium Rhodobacter sphaeroides 2.4.1 PNAS, August 17, 2004; 101(33): 12306 - 12311. [Abstract] [Full Text] [PDF]
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