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Microbiology 149 (2003), 729-737; DOI  10.1099/mic.0.25645-0
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Microbiology 149 (2003), 729-737; DOI  10.1099/mic.0.25645-0
© 2003 Society for General Microbiology

Correlation of the rate of protein synthesis and the third power of the RNA : protein ratio in Escherichia coli and Mycobacterium tuberculosis

Robert A. Cox

Division of Mycobacterial Research, National Institute for Medical Research, London NW7 1AA, UK

Correspondence
Robert A. Cox
rcox{at}nimr.mrc.ac.uk

In order to further understand the different physiological states of the tubercle bacillus, a frame of reference was sought by first correlating the macromolecular compositions of Escherichia coli with specific growth rates and also with the rates of protein synthesis. Data for DNA : protein : RNA were converted to the average amounts of DNA [mDNA(av)], protein [mp(av)] and RNA [mRNA(av)] per cell. The specific growth rate µ was found to be directly proportional to mRNA(av)/mp(av). The specific protein synthesis rate per average cell [{omega}p(av)] was shown to be directly proportional to the third power of the ratio mRNA(av)/mp(av) which reflects the ribosome concentration. The equations derived were shown apply to both E. coli (µ=1·73 h-1) and Mycobacterium bovis BCG (µ=0·029 h-1).

Abbreviations: BCG, bacillus Calmette–Guérin




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