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Microbiology 149 (2003), 2129-2136; DOI  10.1099/mic.0.26349-0
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Microbiology 149 (2003), 2129-2136; DOI  10.1099/mic.0.26349-0
© 2003 Society for General Microbiology

Glucose uptake in germinating Aspergillus nidulans conidia: involvement of the creA and sorA genes

Andrew P. MacCabe1, Pilar Miró1, Luisa Ventura1 and Daniel Ramón1,2

1 Instituto de Agroquímica y Tecnología de Alimentos, CSIC, Apartado de Correos 73, Burjassot, 46100 Valencia, Spain
2 Departamento de Medicina Preventiva y Salud Pública, Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia, Universitat de València, Avenida Vicente Andrés Estellés s/n, 46100-Burjassot, Valencia, Spain

Correspondence
Andrew P. MacCabe
andrew{at}iata.csic.es

D-Glucose uptake in germinating wild-type Aspergillus nidulans conidia is an energy-requiring process mediated by at least two transport systems of differing affinities for glucose: a low-affinity system (Km~1·4 mM) and a high-affinity system (Km~16 µM). The low-affinity system is inducible by glucose; the high-affinity system is subject to glucose repression effected by the carbon catabolite repressor CreA and is absent in sorA3 mutant conidia, which exhibit resistance to L-sorbose toxicity. An intermediate-affinity system (Km~400 µM) is present in sorA3 conidia germinating in derepressing conditions. creA derepressed mutants show enhanced sensitivity to L-sorbose. The high-affinity uptake system appears to be responsible for the uptake of this toxic sugar.

Abbreviations: CCR, carbon catabolite repression; CM, complete medium; GM, germination medium; SGM, supplemented GM




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