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Microbiology 149 (2003), 2435-2442; DOI  10.1099/mic.0.26313-0
© 2003 Society for General Microbiology

Streptomyces lividans contains a minimal functional signal recognition particle that is involved in protein secretion

Arantxa Palacín, Ricardo de la Fuente, Inmaculada Valle, Luis A. Rivas and Rafael P. Mellado

Centro Nacional de Biotecnología, Campus de la Universidad Autónoma, Cantoblanco, 28049 Madrid, Spain

Correspondence
Rafael P. Mellado
rpmellado{at}cnb.uam.es

The bacterial version of the mammalian signal recognition particle (SRP) is well conserved and essential to all known bacteria. The genes for the Streptomyces lividans SRP components have been cloned and characterized. FtsY resembles the mammalian SRP receptor and the S. lividans SRP consists of Ffh, a homologue of the mammalian SRP54 protein, and scRNA, which is a small size RNA of 82 nt in length. Co-immunoprecipitation studies confirmed that Ffh and scRNA are probably the only components of the S. lividans SRP and that pre-agarase can co-immunoprecipitate with Ffh, suggesting that the SRP is involved in targeting secretory proteins.

Abbreviations: His6, hexahistidine; scRNA, small cytoplasmic RNA; SRP, signal recognition particle

The Streptomyces lividans ffh, scRNA and ftsY gene sequences described in this article have been deposited in GenBank under accession numbers AF071565, AY081854 and AY140960, respectively.




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