| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
1 Department of Molecular Biology and Genetics and Program in Cellular, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA
2 Department of Molecular Medicine, Johns Hopkins University School of Medicine, 725 N. Wolfe Street, Baltimore, MD 21205, USA
Correspondence
Brendan P. Cormack
bcormack{at}bs.jhmi.edu
Glycosylphosphatidylinositol (GPI)-anchored cell wall proteins (GPI-CWPs) play an important role in the structure and function of the cell wall in Saccharomyces cerevisiae and other fungi. While the majority of characterized fungal GPI-anchored proteins localize to the cell wall, a subset of GPI proteins are thought to reside at the plasma membrane and not to traffic significantly to the cell wall. The amino acids immediately upstream of the site of GPI anchor addition (the 
site) are the primary signal determining whether a GPI protein localizes to the cell wall or to the plasma membrane. Here, evidence was found that in addition to this -proximal signal, other sequences in the protein can impact the distribution of GPI proteins between cell wall and membrane. In particular, it was found that long regions rich in serine and threonine residues (a feature of many cell wall proteins) can override the -proximal signal and redirect a model GPI plasma membrane protein to the cell wall.
This article has been cited by other articles:
|
|
 |
|
  E. Moreno-Ruiz, G. Ortu, P. W. J. de Groot, F. Cottier, C. Loussert, M.-C. Prevost, C. de Koster, F. M. Klis, S. Goyard, and C. d'Enfert The GPI-modified proteins Pga59 and Pga62 of Candida albicans are required for cell wall integrity Microbiology, June 1, 2009; 155(6): 2004 - 2020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Mao, Z. Zhang, C. Gast, and B. Wong C-Terminal Signals Regulate Targeting of Glycosylphosphatidylinositol-Anchored Proteins to the Cell Wall or Plasma Membrane in Candida albicans Eukaryot. Cell, November 1, 2008; 7(11): 1906 - 1915. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Orlean and A. K. Menon Thematic review series: Lipid Posttranslational Modifications. GPI anchoring of protein in yeast and mammalian cells, or: how we learned to stop worrying and love glycophospholipids J. Lipid Res., May 1, 2007; 48(5): 993 - 1011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Bowman, A. Piwowar, M. Al Dabbous, J. Vierula, and S. J. Free Mutational Analysis of the Glycosylphosphatidylinositol (GPI) Anchor Pathway Demonstrates that GPI-Anchored Proteins Are Required for Cell Wall Biogenesis and Normal Hyphal Growth in Neurospora crassa Eukaryot. Cell, March 1, 2006; 5(3): 587 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Xu, P. Takvorian, A. Cali, F. Wang, H. Zhang, G. Orr, and L. M. Weiss Identification of a New Spore Wall Protein from Encephalitozoon cuniculi Infect. Immun., January 1, 2006; 74(1): 239 - 247. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Y. Yin, P. W. J. de Groot, H. L. Dekker, L. de Jong, F. M. Klis, and C. G. de Koster Comprehensive Proteomic Analysis of Saccharomyces cerevisiae Cell Walls: IDENTIFICATION OF PROTEINS COVALENTLY ATTACHED VIA GLYCOSYLPHOSPHATIDYLINOSITOL REMNANTS OR MILD ALKALI-SENSITIVE LINKAGES J. Biol. Chem., May 27, 2005; 280(21): 20894 - 20901. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Duran and C. Nombela Fungal cell wall biogenesis: building a dynamic interface with the environment Microbiology, October 1, 2004; 150(10): 3099 - 3103. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| INT J SYST EVOL MICROBIOL | MICROBIOLOGY | J GEN VIROL |
| J MED MICROBIOL | ALL SGM JOURNALS | |
