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Microbiology 150 (2004), 3441-3449; DOI  10.1099/mic.0.27356-0
© 2004 Society for General Microbiology

GerE-independent expression of cotH leads to CotC accumulation in the mother cell compartment during Bacillus subtilis sporulation

Loredana Baccigalupi1,{ddagger}, Gaetano Castaldo1,{dagger},{ddagger}, Giuseppina Cangiano1, Rachele Isticato1, Rosangela Marasco2, Maurilio De Felice1 and Ezio Ricca1

1 Dipartimento di Fisiologia Generale ed Ambientale, Università Federico II, via Mezzocannone 16, 80134 Napoli, Italy
2 Dipartimento di Scienze della Vita, Seconda Università di Napoli, Caserta, Italy

Correspondence
Ezio Ricca
ericca{at}unina.it

Evidence is presented that expression of the cotH gene, whose product is required for the correct assembly of the Bacillus subtilis spore coat, is negatively controlled by the transcriptional regulator GerE. Mutations in the GerE-box, present in the cotH promoter region, increased expression of this gene, which also remained elevated during late stages of sporulation, when in wild-type cells cotH is normally turned off. Such alterations of cotH expression did not significantly affect spore coat structure or function but caused the accumulation of CotC molecules in the mother cell compartment, most likely as a consequence of CotH-mediated protection of CotC.

Abbreviations: DMS, dimethyl sulfate

{dagger}Present address: The School of Pharmacy, University of London, London, UK.

{ddagger}These two authors contributed equally to this work.




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