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Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp.

¹ Department of Plant Sciences, Montana State University, Bozeman, MT 59717, USA
² Department of Integrated Biology, Brigham Young University, Provo, UT 84602, USA
³ Department of Microbiology, Brigham Young University, Provo, UT 84602, USA
⁴ Department of Neurology, Harvard Medical School, and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA
⁵ Department of Chemistry, Montana State University, Bozeman, MT 59717, USA
⁶ Novozymes Biotech Inc., 1445 Drew Ave, Davis, CA 95616, USA

Correspondence
Gary Strobel
uplgs{at}montana.edu

Coronamycin is a complex of novel peptide antibiotics with activity against pythiaceous fungi and the human fungal pathogen Cryptococcus neoformans. It is also active against the malarial parasite, Plasmodium falciparum, with an IC₅₀ of 9·0 ng ml^–1. Coronamycin is produced by a verticillate Streptomyces sp. isolated as an endophyte from an epiphytic vine, Monstera sp., found in the Manu region of the upper Amazon of Peru. Bioassay-guided fractionation of the fermentation broths of this endophyte on silica gel and HPLC chromatography yielded two principal, inseparable, peptides with masses of 1217·9 and 1203·8 Da. Three other minor, but related components, are also present in the preparation. Amino acid analysis of coronamycin revealed residues of component 1, component 2, methionine, tyrosine and leucine at a ratio of 2 : 2 : 1 : 1 : 3. Other compounds with antifungal activities are also produced by this endophytic streptomycete.

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