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Microbiology 151 (2005), 4005-4013; DOI  10.1099/mic.0.27925-0
© 2005 Society for General Microbiology

Complete and variant forms of the ‘gonococcal genetic island’ in Neisseria meningitidis

Lori A. S. Snyder1, Stephen A. Jarvis2 and Nigel J. Saunders1

1 Bacterial Pathogenesis and Functional Genomics Group, Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
2 Department of Computer Science, University of Warwick, Coventry CV4 7AL, UK

Correspondence
Nigel J. Saunders
Nigel.Saunders{at}path.ox.ac.uk

Comparative genome hybridization using the pan-Neisseria microarray identified genes from the gonococcal genetic island (GGI) within Neisseria meningitidis strains of serogroups W-135, H, and Z. While some of these strains contain nearly all of the genes of the GGI, there are differences in the presence of some of these genes between the strains, including between those of the same serogroup. Attempts were then made to determine the location of the GGI in these meningococci. Sequencing of Neisseria gonorrhoeae strain MS11 revealed that the GGI is a conjugative plasmid that can be chromosomally integrated at the dif sites near ung and can also be present in its circularized form. In N. meningitidis, a dif site is present in this location and also serves as the point of chromosomal integration of the GGI in this species.

Abbreviations: CDS, coding sequence; CGH, comparative genome hybridization; GGI, gonococcal genetic island; MLST, multilocus sequence typing; MME, minimal mobile element

The GenBank/EMBL/DDBJ accession numbers for the sequences reported in this paper are DQ171942, DQ171943, DQ171944, and DQ171945.




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