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Microbiology 151 (2005), 579-588; DOI  10.1099/mic.0.27520-0
© 2005 Society for General Microbiology

Virulence attenuation in Salmonella enterica rcsC mutants with constitutive activation of the Rcs system

Clara B. García-Calderón, Meritxell García-Quintanilla, Josep Casadesús and Francisco Ramos-Morales

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Apartado 1095, 41080 Sevilla, Spain

Correspondence
Francisco Ramos-Morales
framos{at}us.es

Mutations in rcsC that result in constitutive colanic acid capsule synthesis were obtained in Salmonella enterica serovar Typhimurium. Most rcsC alleles were dominant; however, recessive rcsC alleles were also found, in agreement with the postulated double role (positive and negative) of RcsC on the activation of the RcsB/C phosphorelay system. Salmonella rcsC mutants with constitutive activation of the Rcs system are severely attenuated for virulence in BALB/c mice and their degree of attenuation correlates with the level of Rcs activation. Partial relief of attenuation by a gmm mutation indicates that capsule overproduction is one of the factors leading to avirulence in constitutively activated rcsC mutants.

Abbreviations: CI, competitive index; Km, kanamycin




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