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School of Biosciences, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Correspondence
Jon L. Hobman
J.L.Hobman{at}bham.ac.uk
The gene expression profile of Escherichia coli K-12 MG1655 grown in minimal medium supplemented with elevated copper concentrations (as copper-glycine) has been analysed using whole-genome oligonucleotide microarrays. At 750 µM copper-glycine, the expression of both the cue and cus copper-export systems is evident. At near-lethal copper concentrations (2 mM copper-glycine), the expression of these two regulons increases significantly. Other regulons with increased transcription in response to elevated concentrations of copper-glycine include those for the superoxide stress response, iron homeostasis, and envelope stress. Furthermore, a variety of ORFs with decreased expression in response to increased copper-glycine has been identified, including the zinc ABC transporter and genes involved in the chemotactic response.
Present address: BBSRC, Polaris House, North Star Avenue, Swindon SN2 1VH, UK.
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