HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Buist, G. Articles by Kuipers, O. P. Search for Related Content PubMed PubMed Citation Articles by Buist, G. Articles by Kuipers, O. P. Agricola Articles by Buist, G. Articles by Kuipers, O. P.

Different subcellular locations of secretome components of Gram-positive bacteria

Girbe Buist^,

Anja N. J. A. Ridder

Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands

Correspondence
Anja N. J. A. Ridder
a.n.j.a.ridder{at}rug.nl

Gram-positive bacteria contain different types of secretion systems for the transport of proteins into or across the cytoplasmic membrane. Recent studies on subcellular localization of specific components of these secretion systems and their substrates have shown that they can be present at various locations in the cell. The translocons of the general Sec secretion system in the rod-shaped bacterium Bacillus subtilis have been shown to localize in spirals along the cytoplasmic membrane, whereas the translocons in the coccoid Streptococcus pyogenes are located in a microdomain near the septum. In both bacteria the Sec translocons appear to be located near the sites of cell wall synthesis. The Tat secretion system, which is used for the transport of folded proteins, probably localizes in the cytoplasmic membrane and at the cell poles of B. subtilis. In Lactococcus lactis the ABC transporter dedicated to the transport of a small antimicrobial peptide is distributed throughout the membrane. Possible mechanisms for maintaining the localization of these secretion machineries involve their interaction with proteins of the cytoskeleton or components of the cell wall synthesis machinery, or the presence of lipid subdomains surrounding the transport systems.

Present address: Laboratory of Molecular Bacteriology, Department of Medical Microbiology, University Medical Center Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.

This article has been cited by other articles:

				Y. Chen, X. Zhang, D. Manias, H.-J. Yeo, G. M. Dunny, and P. J. Christie Enterococcus faecalis PcfC, a Spatially Localized Substrate Receptor for Type IV Secretion of the pCF10 Transfer Intermediate J. Bacteriol., May 15, 2008; 190(10): 3632 - 3645. [Abstract] [Full Text] [PDF]

				B. Zekarias, H. Mo, and R. Curtiss III Recombinant Attenuated Salmonella enterica Serovar Typhimurium Expressing the Carboxy-Terminal Domain of Alpha Toxin from Clostridium perfringens Induces Protective Responses against Necrotic Enteritis in Chickens Clin. Vaccine Immunol., May 1, 2008; 15(5): 805 - 816. [Abstract] [Full Text] [PDF]