HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Vesterlund, S. Articles by Ouwehand, A. C. Search for Related Content PubMed PubMed Citation Articles by Vesterlund, S. Articles by Ouwehand, A. C. Agricola Articles by Vesterlund, S. Articles by Ouwehand, A. C.

Staphylococcus aureus adheres to human intestinal mucus but can be displaced by certain lactic acid bacteria

¹ Functional Foods Forum, Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
² Department of Environmental Engineering and Biotechnology, Tampere University of Technology, Tampere, Finland
³ Danisco Innovations, Kantvik, Finland

Correspondence
Satu Vesterlund
satu.vesterlund{at}utu.fi

There is increasing evidence that Staphylococcus aureus may colonize the intestinal tract, especially among hospitalized patients. As Staph. aureus has been found to be associated with certain gastrointestinal diseases, it has become important to study whether this bacterium can colonize the intestinal tract and if so, whether it is possible to prevent colonization. Adhesion is the first step in colonization; this study shows that Staph. aureus adheres to mucus from resected human intestinal tissue. Certain lactic acid bacteria (LAB), mainly commercial probiotics, were able to reduce adhesion and viability of adherent Staph. aureus. In displacement assays the amount of adherent Staph. aureus in human intestinal mucus was reduced 39–44 % by Lactobacillus rhamnosus GG, Lactococcus lactis subsp. lactis and Propionibacterium freudenreichii subsp. shermanii. Moreover, adherent Lactobacillus reuteri, Lc. lactis and P. freudenreichii reduced viability of adherent Staph. aureus by 27–36 %, depending on the strain, after 2 h incubation. This was probably due to the production of organic acids and hydrogen peroxide and possibly in the case of L. reuteri to the production of reuterin. This study shows for the first time that Staph. aureus can adhere to human intestinal mucus and adherent bacteria can be displaced and killed by certain LAB strains via in situ production of antimicrobial substances.

This article has been cited by other articles:

				L. Nazef, Y. Belguesmia, A. Tani, H. Prevost, and D. Drider Identification of Lactic Acid Bacteria from Poultry Feces: Evidence on Anti-Campylobacter and Anti-Listeria Activities Poult. Sci., February 1, 2008; 87(2): 329 - 334. [Abstract] [Full Text] [PDF]

				S. Nuding, K. Fellermann, J. Wehkamp, and E. F Stange Reduced mucosal antimicrobial activity in Crohn's disease of the colon Gut, September 1, 2007; 56(9): 1240 - 1247. [Abstract] [Full Text] [PDF]