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AopP, a type III effector protein of Aeromonas salmonicida, inhibits the NF-B signalling pathway

¹ Institute of Veterinary Bacteriology, Vetsuisse Faculty, Universität Bern, Länggassstrasse 122, Postfach, CH-3001 Bern, Switzerland
² Division of Molecular Pathology, Vetsuisse Faculty, Universität Bern, Länggassstrasse 122, Postfach, CH-3001 Bern, Switzerland
³ Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX, USA

Correspondence
Joachim Frey
joachim.frey{at}vbi.unibe.ch

Aeromonas salmonicida subsp. salmonicida contains a functional type III secretion system that is responsible for the secretion of the ADP-ribosylating toxin AexT. In this study, the authors identified AopP as a second effector protein secreted by this system. The aopP gene was detected in both typical and atypical A. salmonicida isolates and was found to be encoded on a small plasmid of approximately 6.4 kb. Sequence analysis indicates that AopP is a member of the YopJ family of effector proteins, a group of proteins that interfere with mitogen-activated protein kinase (MAPK) and/or nuclear factor kappa B (NF-B) signalling pathways. AopP inhibits the NF-B pathway downstream of IB kinase (IKK) activation, while a catalytically inactivated mutant, AopPC177A, does not possess this inhibitory effect. Unlike other effectors of the YopJ family, such as YopJ and VopA, AopP does not inhibit the MAPK signalling pathway.

The GenBank/EMBL/DDBJ accession number for the plasmid pAsal1 sequence reported in this paper is AJ508382.

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