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Microbiology 153 (2007), 357-365; DOI  10.1099/mic.0.2006/002444-0
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Microbiology 153 (2007), 357-365; DOI  10.1099/mic.0.2006/002444-0
© 2007 Society for General Microbiology

Characterization of the last step of the aerobic phenylacetic acid degradation pathway

Juan Nogales1, Raffaella Macchi2, Federico Franchi2, Dagania Barzaghi2, Cristina Fernández1, José L. García1, Giovanni Bertoni2 and Eduardo Díaz1

1 Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas-CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
2 Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy

Correspondence
Eduardo Díaz
ediaz{at}cib.csic.es

Phenylacetic acid (PA) degradation in bacteria involves an aerobic hybrid pathway encoded by the paa gene cluster. It is shown here that succinyl-CoA is one of the final products of this pathway in Pseudomonas putida and Escherichia coli. Moreover, in vivo and in vitro studies revealed that the paaE gene encodes the beta-ketoadipyl-CoA thiolase that catalyses the last step of the PA catabolic pathway, i.e. the thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA. Succinyl-CoA is suggested as a common final product of aerobic hybrid pathways devoted to the catabolism of aromatic compounds.


Abbreviations: PA, phenylacetic acid; TCA cycle, tricarboxylic acid cycle




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