Microbiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Microbiology 153 (2007), 357-365; DOI  10.1099/mic.0.2006/002444-0
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nogales, J.
Right arrow Articles by Díaz, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nogales, J.
Right arrow Articles by Díaz, E.
Agricola
Right arrow Articles by Nogales, J.
Right arrow Articles by Díaz, E.
Microbiology 153 (2007), 357-365; DOI  10.1099/mic.0.2006/002444-0
© 2007 Society for General Microbiology

Characterization of the last step of the aerobic phenylacetic acid degradation pathway

Juan Nogales1, Raffaella Macchi2, Federico Franchi2, Dagania Barzaghi2, Cristina Fernández1, José L. García1, Giovanni Bertoni2 and Eduardo Díaz1

1 Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas-CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
2 Dipartimento di Scienze Biomolecolari e Biotecnologie, Università degli Studi di Milano, Via Celoria 26, 20133 Milan, Italy

Correspondence
Eduardo Díaz
ediaz{at}cib.csic.es

Phenylacetic acid (PA) degradation in bacteria involves an aerobic hybrid pathway encoded by the paa gene cluster. It is shown here that succinyl-CoA is one of the final products of this pathway in Pseudomonas putida and Escherichia coli. Moreover, in vivo and in vitro studies revealed that the paaE gene encodes the beta-ketoadipyl-CoA thiolase that catalyses the last step of the PA catabolic pathway, i.e. the thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA. Succinyl-CoA is suggested as a common final product of aerobic hybrid pathways devoted to the catabolism of aromatic compounds.

Abbreviations: PA, phenylacetic acid; TCA cycle, tricarboxylic acid cycle




This article has been cited by other articles:


Home page
 MicrobiologyHome page
J. Nikodinovic-Runic, M. Flanagan, A. R. Hume, G. Cagney, and K. E. O'Connor
Analysis of the Pseudomonas putida CA-3 proteome during growth on styrene under nitrogen-limiting and non-limiting conditions
Microbiology, October 1, 2009; 155(10): 3348 - 3361.
[Abstract] [Full Text] [PDF]

Home page
 J. Bacteriol.Home page
R. J. Law, J. N. R. Hamlin, A. Sivro, S. J. McCorrister, G. A. Cardama, and S. T. Cardona
A Functional Phenylacetic Acid Catabolic Pathway Is Required for Full Pathogenicity of Burkholderia cenocepacia in the Caenorhabditis elegans Host Model
J. Bacteriol., November 1, 2008; 190(21): 7209 - 7218.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2007 Society for General Microbiology.