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Effects of -phosphoglucomutase deficiency on cell wall properties and fitness in Streptococcus gordonii

Département de Microbiologie Fondamentale, Bâtiment Biophore, Université de Lausanne, Quartier UNIL-Sorge, CH-1015 Lausanne, Switzerland

Correspondence
Vladimir Lazarevic
vladimir.lazarevic{at}unil.ch

Streptococcus gordonii -phosphoglucomutase, which converts glucose 6-phosphate to glucose 1-phosphate, is encoded by pgm. The pgm transcript is monocistronic and is initiated from a ^A-like promoter. Mutants with a gene disruption in pgm exhibited an altered cell wall muropeptide pattern and a lower teichoic acid content, and had reduced fitness both in vitro and in vivo. In vitro, the reduced fitness included reduced growth, reduced viability in the stationary phase and increased autolytic activity. In vivo, the pgm-deficient strain had a lower virulence in a rat model of experimental endocarditis.

The GenBank/EMBL/DDBJ accession number for the nucleotide sequence of Streptococcus gordonii pgm reported in this paper is DQ234767.

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