Microbiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplementary data
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Murata, M.
Right arrow Articles by Shirai, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Murata, M.
Right arrow Articles by Shirai, M.
Agricola
Right arrow Articles by Murata, M.
Right arrow Articles by Shirai, M.
Microbiology 153 (2007), 585-592; DOI  10.1099/mic.0.29213-0
© 2007 Society for General Microbiology

Chlamydial SET domain protein functions as a histone methyltransferase

Masayuki Murata1, Yoshinao Azuma1, Koshiro Miura1,2,{dagger}, Mohd. Akhlakur Rahman1, Minenosuke Matsutani1, Masahiro Aoyama1, Harumi Suzuki1, Kazuro Sugi2 and Mutsunori Shirai1

1 Department of Microbiology and Immunology, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan
2 Department of Clinical Research, National Sanyo Hospital, 685 Higashi-Kiwa, Ube, Yamaguchi 755-0241, Japan

Correspondence
Yoshinao Azuma
yazuma{at}yamaguchi-u.ac.jp
Mutsunori Shirai
mshirai{at}yamaguchi-u.ac.jp

SET domain genes have been identified in numbers of bacterial genomes based on similarity to SET domains of eukaryotic histone methyltransferases. Herein, a Chlamydophila pneumoniae SET domain gene was clarified to be coincidently expressed with hctA and hctB genes encoding chlamydial histone H1-like proteins, Hc1 and Hc2, respectively. The SET domain protein (cpnSET) is localized in chlamydial cells and interacts with Hc1 and Hc2 through the C-terminal SET domain. As expected from conservation of catalytic sites in cpnSET, it functions as a protein methyltransferase to murine histone H3 and Hc1. However, little is known about protein methylation in the molecular pathogenesis of chlamydial infection. cpnSET may play an important role in chlamydial cell maturation due to modification of chlamydial histone H1-like proteins.

Abbreviations: cpnSET, Chlamydophila pneumoniae SET domain protein; EB, elementary body; RB, reticulate body; FCS, fetal calf serum; GST, glutathione S-transferase; h.p.i., hours post-infection

A supplementary table and three supplementary figures are available with the online version of this paper.

{dagger}Present address: Department of Veterinary Biosciences, the Ohio State University, 1900 Coffey Rd, Columbus, OH 43210, USA.




This article has been cited by other articles:


Home page
 DNA ResHome page
K. Miura, H. Toh, H. Hirakawa, M. Sugii, M. Murata, K. Nakai, K. Tashiro, S. Kuhara, Y. Azuma, and M. Shirai
Genome-wide Analysis of Chlamydophila pneumoniae Gene Expression at the Late Stage of Infection
DNA Res, April 1, 2008; 15(2): 83 - 91.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 2007 Society for General Microbiology.