HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rezwan, M. Articles by Sander, P. Search for Related Content PubMed PubMed Citation Articles by Rezwan, M. Articles by Sander, P. Agricola Articles by Rezwan, M. Articles by Sander, P.

Lipoprotein synthesis in mycobacteria

¹ Institut für Medizinische Mikrobiologie, Universität Zürich, Gloriastrasse 32, CH-8006 Zürich, Switzerland
² Nationales Zentrum für Mykobakterien, Gloriastrasse 30, CH-8006 Zürich, Switzerland

Correspondence
Peter Sander
psander{at}immv.unizh.ch

Lipoproteins are a functionally diverse class of secreted bacterial proteins characterized by an N-terminal lipid moiety. The lipid moiety serves to anchor these proteins to the cell surface. Lipoproteins are synthesized as pre-prolipoproteins and mature by post-translational modifications. The post-translational modifications are directed by the lipobox motif located within the signal peptide. Enzymes involved in lipoprotein synthesis are essential in Gram-negative bacteria but not in Gram-positve bacteria. Inactivation of genes involved in lipoprotein synthesis attenuates a variety of Gram-positive pathogens, including Mycobacterium tuberculosis. The attenuated phenotype of these mutants indicates an important role of lipoproteins and lipoprotein synthesis in bacterial virulence. M. tuberculosis, the causative agent of tuberculosis, is one of the most devastating pathogens in the world. This article reviews recent findings on the synthesis, localization and function of lipoproteins in mycobacteria.

This article has been cited by other articles:

				S. K. Rampini, P. Selchow, C. Keller, S. Ehlers, E. C. Bottger, and P. Sander LspA inactivation in Mycobacterium tuberculosis results in attenuation without affecting phagosome maturation arrest Microbiology, October 1, 2008; 154(10): 2991 - 3001. [Abstract] [Full Text] [PDF]

				S. Guglielmetti, I. Tamagnini, D. Mora, M. Minuzzo, A. Scarafoni, S. Arioli, J. Hellman, M. Karp, and C. Parini Implication of an Outer Surface Lipoprotein in Adhesion of Bifidobacterium bifidum to Caco-2 Cells Appl. Envir. Microbiol., August 1, 2008; 74(15): 4695 - 4702. [Abstract] [Full Text] [PDF]

				T. P. Stinear, T. Seemann, P. F. Harrison, G. A. Jenkin, J. K. Davies, P. D.R. Johnson, Z. Abdellah, C. Arrowsmith, T. Chillingworth, C. Churcher, et al. Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis Genome Res., May 1, 2008; 18(5): 729 - 741. [Abstract] [Full Text] [PDF]

				M. Bastian, T. Braun, H. Bruns, M. Rollinghoff, and S. Stenger Mycobacterial Lipopeptides Elicit CD4+ CTLs in Mycobacterium tuberculosis-Infected Humans J. Immunol., March 1, 2008; 180(5): 3436 - 3446. [Abstract] [Full Text] [PDF]