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Microbiology 153 (2007), 1842-1851; DOI  10.1099/mic.0.2006/004390-0
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Microbiology 153 (2007), 1842-1851; DOI  10.1099/mic.0.2006/004390-0
© 2007 Society for General Microbiology

The phrA gene of Rhodobacter sphaeroides encodes a photolyase and is regulated by singlet oxygen and peroxide in a {sigma}E-dependent manner

Anne-Kathrin Hendrischk, Stephan Braatsch{dagger}, Jens Glaeser and Gabriele Klug

Institut für Mikrobiologie und Molekularbiologie, University of Giessen, Heinrich-Buff-Ring 26-32, D-35392 Giessen, Germany

Correspondence
Gabriele Klug
Gabriele.Klug{at}mikro.bio.uni-giessen.de

The genome of the facultatively photosynthetic bacterium Rhodobacter sphaeroides encodes three proteins of the photolyase/cryptochrome family. This paper shows that phrA (RSP2143) encodes a functional photolyase, which is an enzyme that repairs UV radiation-induced DNA damage in a blue light dependent manner. Expression of phrA is upregulated in response to light, with no photoreceptor or the photosynthetic electron transport being involved. The results reveal that singlet oxygen and hydrogen peroxide dependent signals are transmitted by the {sigma}E factor and the anti-{sigma}E factor ChrR affecting phrA expression, while superoxide anions do not stimulate phrA expression. Thus, the {sigma}E regulon is involved not only in the response to singlet oxygen but also in the hydrogen peroxide response.

Abbreviations: CPD, cyclobutane pyrimidine dimer; DASH, Drosophila, Arabidopsis, Synechocystis, Human; HDF, 8-hydroxy-7,8-didemethyl-5-deazariboflavin

{dagger}Present address: Department of Microbiology and Immunology, University of British Columbia Life Sciences Centre, 4557-2350 Health Sciences Mall, Vancouver, BC V6T 1Z3, Canada.






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Copyright © 2007 Society for General Microbiology.