HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Free via Open Access: OA OA Free Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Påhlman, L. I. Articles by Herwald, H. Search for Related Content PubMed PubMed Citation Articles by Påhlman, L. I. Articles by Herwald, H. Agricola Articles by Påhlman, L. I. Articles by Herwald, H.

M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes

Department of Clinical Sciences, Lund, Section for Clinical and Experimental Infection Medicine, Lund University, SE-22184 Lund, Sweden

Correspondence
Lisa I. Påhlman
Lisa.Pahlman{at}med.lu.se

Invasive infections caused by the important pathogen Streptococcus pyogenes are often associated with disturbed blood coagulation in the human host, and may in severe cases develop into the life-threatening condition disseminated intravascular coagulation. In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of pro-coagulant activity, which was mediated by an upregulation of tissue factor on monocytes. Analysis of the resulting clots by transmission electron microscopy revealed that the cells were covered with a fibrin network that seemed to originate from the cell surface. Taken together, the results imply an important role for M proteins in the induction of haemostatic disorders in invasive streptococcal infectious diseases.