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Microbiology 153 (2007), 2984-2988; DOI  10.1099/mic.0.2007/008888-0
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Microbiology 153 (2007), 2984-2988; DOI  10.1099/mic.0.2007/008888-0
© 2007 Society for General Microbiology

A generalized transducing phage for the murine pathogen Citrobacter rodentium

Nicola K. Petty1, Ana L. Toribio2, David Goulding2, Ian Foulds1, Nicholas Thomson2, Gordon Dougan2 and George P. C. Salmond1

1 Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, UK
2 Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK

Correspondence
George P. C. Salmond
gpcs{at}mole.bio.cam.ac.uk

A virulent phage ({phi}CR1) capable of generalized transduction in Citrobacter rodentium was isolated from the environment and characterized. C. rodentium is a natural pathogen of mice, causing transmissible murine colonic hyperplasia. Sequencing of its genome has recently been completed and will soon be fully annotated and published. C. rodentium is an important model organism for infections caused by the human pathogens enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC). {phi}CR1 uses a lipopolysaccharide receptor, has a genome size of approximately 300 kb, and is able to transduce a variety of markers. {phi}CR1 is the first reported transducing phage for C. rodentium and will be a useful tool for functional genomic analysis of this important natural murine pathogen.

Abbreviations: Cm, chloramphenicol; Nal, nalidixic acid






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