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New insights into the BzdR-mediated transcriptional regulation of the anaerobic catabolism of benzoate in Azoarcus sp. CIB

Gonzalo Durante-Rodríguez

M. Teresa Zamarro

Departamento de Microbiología Molecular, Centro de Investigaciones Biológicas-CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain

Correspondence
Manuel Carmona
mcarmona{at}cib.csic.es

The expression of the bzd genes involved in the anaerobic degradation of benzoate in Azoarcus sp. CIB is controlled by the specific BzdR transcriptional repressor at the P_N promoter. This catabolic promoter is also subject to catabolite repression by some organic acids. In vivo and in vitro experiments have shown that BzdR behaves as a repressor of the P_R promoter by overlapping the transcription initiation site as well as the –35 and –10 boxes, benzoyl-CoA being the inducer molecule. In addition, by using a P_N : : lacZ fusion both in Azoarcus sp. CIB and in an isogenic strain lacking the bzdR gene, we have shown that the succinate-dependent catabolite repression requires participation of the BzdR repressor.

These authors contributed equally to this work.