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Microbiology 155 (2009), 1-8; DOI  10.1099/mic.0.023903-0IMMEDIATE OPEN ACCESS ARTICLE
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Microbiology 155 (2009), 1-8; DOI  10.1099/mic.0.023903-0
© 2009 Society for General Microbiology

Mini-Review

A pivotal role for the response regulator DegU in controlling multicellular behaviour

Ewan J. Murray, Taryn B. Kiley and Nicola R. Stanley-Wall

Division of Molecular and Environmental Microbiology, College of Life Sciences, MSI/WTB/JBC Complex, University of Dundee, Dundee DD1 5EH, UK

Correspondence
Nicola R. Stanley-Wall
n.r.stanleywall{at}dundee.ac.uk

Bacteria control multicellular behavioural responses, including biofilm formation and swarming motility, by integrating environmental cues through a complex regulatory network. Heterogeneous gene expression within an otherwise isogenic cell population that allows for differentiation of cell fate is an intriguing phenomenon that adds to the complexity of multicellular behaviour. This review focuses on recent data about how DegU, a pleiotropic response regulator, co-ordinates multicellular behaviour in Bacillus subtilis. We review studies that challenge the conventional understanding of the molecular mechanisms underpinning the DegU regulatory system and others that describe novel targets of DegU during activation of biofilm formation by B. subtilis. We also discuss a novel role for DegU in regulating multicellular processes in the food-borne pathogen Listeria monocytogenes.




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E. J. Murray, M. A. Strauch, and N. R. Stanley-Wall
{sigma}X Is Involved in Controlling Bacillus subtilis Biofilm Architecture through the AbrB Homologue Abh
J. Bacteriol., November 15, 2009; 191(22): 6822 - 6832.
[Abstract] [Full Text] [PDF]


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