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hag expression in Bacillus subtilis is both negatively and positively regulated by ScoC

Prashant Kodgire

School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India

Correspondence
Prashant Kodgire
pkodgire{at}bsd.uchicago.edu

In Bacillus subtilis, motility and chemotaxis require the expression of hag, which encodes flagellin. This gene is transcribed by the ^D form of RNA polymerase and is regulated by a group of proteins called transition state regulators (TSRs). Our studies show that hag transcription is negatively regulated by the transition state regulator ScoC, by binding to its promoter. Furthermore, ScoC, indirectly, also positively regulates hag by increasing the availability of ^D by downregulating the levels of the anti-^D-factor FlgM. We further show that the positive regulation by ScoC predominates over the negative regulation.

Present address: Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL 60637, USA.