HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Supplementary figure Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Brissette, C. A. Articles by Stevenson, B. Search for Related Content PubMed PubMed Citation Articles by Brissette, C. A. Articles by Stevenson, B. Agricola Articles by Brissette, C. A. Articles by Stevenson, B.

The Borrelia burgdorferi outer-surface protein ErpX binds mammalian laminin

Catherine A. Brissette

Ashutosh Verma

Anne E. Cooley

Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY 40536-0298, USA

Correspondence
Brian Stevenson
brian.stevenson{at}uky.edu

The Lyme disease spirochaete, Borrelia burgdorferi, can invade and persistently infect its hosts' connective tissues. We now demonstrate that B. burgdorferi adheres to the extracellular matrix component laminin. The surface-exposed outer-membrane protein ErpX was identified as having affinity for laminin, and is the first laminin-binding protein to be identified in a Lyme disease spirochaete. The adhesive domain of ErpX was shown to be contained within a small, unstructured hydrophilic segment at the protein's centre. The sequence of that domain is distinct from any previously identified bacterial laminin adhesin, suggesting a unique mode of laminin binding.

These authors contributed equally to this work.

Present address: Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

A supplementary sequence alignment is available with the online version of this paper.

This article has been cited by other articles:

				A. Verma, C. A. Brissette, A. Bowman, and B. Stevenson Borrelia burgdorferi BmpA Is a Laminin-Binding Protein Infect. Immun., November 1, 2009; 77(11): 4940 - 4946. [Abstract] [Full Text] [PDF]

				C. A. Brissette, T. Bykowski, A. E. Cooley, A. Bowman, and B. Stevenson Borrelia burgdorferi RevA Antigen Binds Host Fibronectin Infect. Immun., July 1, 2009; 77(7): 2802 - 2812. [Abstract] [Full Text] [PDF]