Microbiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Microbiology 145 (1999), 1919-1926; DOI  10.1099/13500872-145-8-1919
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Strobel, G. A.
Right arrow Articles by Hess, W. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strobel, G. A.
Right arrow Articles by Hess, W. M.
Agricola
Right arrow Articles by Strobel, G. A.
Right arrow Articles by Hess, W. M.

Cryptocandin, a potent antimycotic from the endophytic fungus Cryptosporiopsis cf. quercina

Gary A. Strobel1, R. Vincent Miller1, Concepcion Martinez-Miller1, Margaret M. Condron2, David B. Teplow2 and W. M. Hess3

1 Department of Plant Sciences, Montana State University, Bozeman, MT 59717, USA
2 Brigham and Women's Hospital, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
3 Department of Botany and Range Science, Brigham Young University, Provo, UT 84601, USA

Author for correspondence: Gary A. Strobel. Tel: + 1 406 994 5148. Fax: + 1 406 994 1848. e-mail: uplgs@montana.edu

ABSTRACT

A unique lipopeptide antimycotic, termed cryptocandin, is described from Cryptosporiopsis cf. quercina, an endophytic fungus. Cryptocandin, with a molecular mass of 1079 Da, contains equimolar amounts of 3,4-dihydroxyhomotyrosine, 4-hydroxyproline, threonine, glutamine, 3-hydroxy-4-hydroxymethylproline, 4,5-dihydroxyornithine and palmitic acid. Cryptocandin is chemically related to well-known antimycotics, the echinocandins and pneumocandins, which are produced by such fungi as Zalerion arboricola, Pezicula spp. and Aspergillus spp. Cryptocandin has minimal inhibitory concentration values of 0-03-0-07 µg ml-1 against isolates of Candida albicans, Trichophyton mentagrophytes and Trichophyton rubrum. Cryptocandin is also active against a number of plant-pathogenic fungi including Sclerotinia sclerotiorum and Botrytis cinerea.

Keywords: Trichophyton, endophyte, lipopeptide, 4,4-dimethoxytrityl chloride

Abbreviation: DMT, 4,4-dimethoxytrityl chloride.

Received 18 August 1998; revised 19 April 1999; accepted 23 April 1999.


This article has been cited by other articles:


Home page
 Plant Physiol.Home page
M. Cao, A. Koulman, L. J. Johnson, G. A. Lane, and S. Rasmussen
Advanced Data-Mining Strategies for the Analysis of Direct-Infusion Ion Trap Mass Spectrometry Data from the Association of Perennial Ryegrass with Its Endophytic Fungus, Neotyphodium lolii
Plant Physiology, April 1, 2008; 146(4): 1501 - 1514.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
D. Ezra, U. F. Castillo, G. A. Strobel, W. M. Hess, H. Porter, J. B. Jensen, M. A. M. Condron, D. B. Teplow, J. Sears, M. Maranta, et al.
Coronamycins, peptide antibiotics produced by a verticillate Streptomyces sp. (MSU-2110) endophytic on Monstera sp.
Microbiology, April 1, 2004; 150(4): 785 - 793.
[Abstract] [Full Text] [PDF]

Home page
 Microbiol. Mol. Biol. Rev.Home page
G. Strobel and B. Daisy
Bioprospecting for Microbial Endophytes and Their Natural Products
Microbiol. Mol. Biol. Rev., December 1, 2003; 67(4): 491 - 502.
[Abstract] [Full Text] [PDF]

Home page
 MicrobiologyHome page
U. F. Castillo, G. A. Strobel, E. J. Ford, W. M. Hess, H. Porter, J. B. Jensen, H. Albert, R. Robison, M. A. M. Condron, D. B. Teplow, et al.
Munumbicins, wide-spectrum antibiotics produced by Streptomyces NRRL 30562, endophytic on Kennedia nigriscans
Microbiology, September 1, 2002; 148(9): 2675 - 2685.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Strobel, G. A.
Right arrow Articles by Hess, W. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Strobel, G. A.
Right arrow Articles by Hess, W. M.
Agricola
Right arrow Articles by Strobel, G. A.
Right arrow Articles by Hess, W. M.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
INT J SYST EVOL MICROBIOL MICROBIOLOGY J GEN VIROL
J MED MICROBIOL ALL SGM JOURNALS
Copyright © 1999 Society for General Microbiology.