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Microbiology 151 (2005), 1691-1695; DOI  10.1099/mic.0.27758-0
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Microbiology 151 (2005), 1691-1695; DOI  10.1099/mic.0.27758-0
© 2005 Society for General Microbiology

Secondary metabolites from endophytic Streptomyces aureofaciens CMUAc130 and their antifungal activity

Thongchai Taechowisan1, Chunhua Lu2, Yuemao Shen3 and Saisamorn Lumyong4

1 Department of Biology, Faculty of Science, Silpakorn University, Nakorn Pathom 73000, Thailand
2 School of Life Sciences, Xiamen University, Xiamen 361005, China
3 Kunming Institute of Botany (KIB), The Chinese Academy of Sciences, Kunming 650204, China
4 Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand

Correspondence
Thongchai Taechowisan
tewson84{at}hotmail.com

Streptomyces aureofaciens CMUAc130 was isolated from the root tissue of Zingiber officinale Rosc. (Zingiberaceae). It was an antagonist of Colletotrichum musae and Fusarium oxysporum, the causative agents of anthracnose of banana and wilt of wheat, respectively. Evidence for the in vitro antibiosis of S. aureofaciens CMUAc130 was demonstrated by the zone of fungal-growth inhibition. Microscopic observations showed thickness and bulbous structures at the edges of the inhibited fungal hyphae. The culture filtrate and crude extract from this strain were all inhibitory to tested phytopathogenic fungi. The major active ingredients from the culture filtrate of S. aureofaciens CMUAc130 were purified by silica gel-column chromatography and identified to be (i) 5,7-dimethoxy-4-p-methoxylphenylcoumarin and (ii) 5,7-dimethoxy-4-phenylcoumarin by NMR and mass-spectral data, respectively. Bioassay studies showed that compounds (i) and (ii) had antifungal activities against tested fungi, and their MICs were found to be 120 and 150 µg ml–1, respectively. This is the first report of compounds (i) and (ii) from micro-organisms as active ingredients for the control of phytopathogenic fungi.






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