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Published online ahead of print on 21 April 2009 as doi:10.1099/mic.0.026641-0
Microbiology 2009;155:1934.

Microbiology (2009), DOI 10.1099/mic.0.026641-0
© 2009 Society for General Microbiology
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Microbiology 0 (2009), mic.0.026641; DOI  10.1099/mic.0.026641-0
© 2009 Society for General Microbiology

Pseudomonas aeruginosa Las quorum-sensing autoinducer suppresses the growth and biofilm production in Legionella species

Soichiro Kimura1,5, Kazuhiro Tateda1, Yoshikazu Ishii1, Manabu Horikawa2, Shinichi Miyairi3, Naomasa Gotoh4, Masaji Ishiguro2 and Keizo Yamaguchi1

1 Toho University Faculty of Medicine;
2 Suntory Institute for Bioorganic Research;
3 Nihon University;
4 Kyoto Pharmaceutical University

ABSTRACT

Bacteria commonly communicate with each other by a cell-to-cell signaling mechanism known as quorum sensing. Recent studies have shown that the Las quorum-sensing autoinducer N-(3-oxododecanoyl)-L-homoserine lactone (3-oxo-C12-HSL) of Pseudomonas aeruginosa performs a variety of functions not only in intraspecies signaling but also in interspecies and interkingdom communications. In this study, we report the effects of Pseudomonas 3-oxo-C12-HSL on the growth and suppression of virulence factor in other bacterial species that frequently coexist with P. aeruginosa in nature. It was found that 3-oxo-C12-HSL, but not its analogues, suppressed the growth of Legionella pneumophila in a dose-dependent manner. However, 3-oxo-C12-HSL did not exhibit a growth suppressive effect on Serratia marcescens, Proteus mirabilis, Escherichia coli, Alcaligenes faecalis, and Stenotrophomonas maltophilia. 3-oxo-C12-HSL at 50 µM concentration completely inhibited the growth of L. pneumophila. Additionally, significant suppression of biofilm formation was demonstrated in L. pneumophila exposed to 3-oxo-C12-HSL. Our results suggest that the Pseudomonas quorum-sensing autoinducer 3-oxo-C12-HSL exerts both bacteriostatic and virulence factor-suppressive activities against L. pneumophila alone.

5 E-mail: kimsou{at}med.toho-u.ac.jp






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