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Published online ahead of print on 23 April 2009 as doi:10.1099/mic.0.027417-0
Microbiology 2009;155:2342.

Microbiology (2009), DOI 10.1099/mic.0.027417-0
© 2009 Society for General Microbiology
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Microbiology 0 (2009), mic.0.027417; DOI  10.1099/mic.0.027417-0
© 2009 Society for General Microbiology

Expression of the sarA family of genes in different strains of Staphylococcus aureus

Anand Ballal1 and Adhar C Manna2,3

1 The University of South Dakota;
2 University of South Dakota

ABSTRACT

Expression of genes involved in the pathogenesis of S. aureus is controlled by global regulatory loci including two-component regulatory systems and transcriptional regulators. The staphylococcal specific SarA family of transcription regulators controls large numbers of target genes involved in virulence, autolysis, biofilm formation, stress-responses and metabolic processes and recognizes as a potential therapeutic targets. Expression of some of these important regulators has been examined, mostly in laboratory strains, while the pattern of expression of these genes in other strains, especially clinical isolates is largely unknown. In this report, a comparative analysis of ten sarA family genes was investigated in six different S. aureus strains, including two laboratory (RN6390, SH1000) and four clinical (MW2, Newman, COL and UAMS-1) strains by Northern and Western blots analyses. Transcription of most of the sarA family genes showed a strong growth phase dependence in all strains tested. Among these genes, no difference was observed in expression of the sarA, sarV, sarT and sarU genes, and while a major difference was observed in expression of the sarX gene only in strain RN6390. Expression of mgrA, rot, sarZ, sarR and sarS was observed in all strains but the level of expression varied from strain to strain.

3 E-mail: amanna{at}usd.edu






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