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Cover caption:

Front cover illustration: The Bacillus subtilis sigma Afactor of RNA polymerase (here illustrated by Escherichia colisigma 70 with coordinates obtained from the Protein Data Bank) binds totwo distinct recognition sites in promoters: a normal recognition site(top) and an extended site which differs in several regions (bottom). Theheight of the letters indicates the level of conservation of thenucleotides. Illustration by Hanne Jarmer. See the paper by Jarmeretal. on pp. 2417-2424.