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Front cover illustration: A false-colour electron micrograph of enterohaemorrhagic Escherichia coli (EHEC) adhering to the surface of an enterocyte in the bovine colon on a raised pedestal with localized destruction of the nearby microvilli. The formation of these characteristic 'attaching and effacing' lesions is thought to be important for colonization of the ruminant intestinal tract by EHEC. Courtesy Dr Paul Monaghan, IAH, Pirbright. See the review by Stevens et al. on pp. 3767-3778.