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Cover caption:

Front cover illustration: Restoration of cellular differentiation and pigment production in a bald mutant of Streptomyces tanashiensis (strain CR1) by exogenous supplementation of copper. Strain CR1 was inoculated into a confluent lawn on Bennett's-glucose solid medium, onto which an agar disc (1 cm in diameter) containing 0.1 mM copper sulfate was placed. The whitish colonies around the disc form aerial mycelia and spores, and produce pigment, in marked contrast to the brown-coloured ones far from the disc that only display vegatative growth of substrate mycelia. The photograph was taken after 4 days growth at 28 degrees C. Courtesy Kenji Ueda and Teruhiko Beppu, Nihon University, Kanagawa, Japan. See the paper by Endo et al. on pp. 1767-1776.