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Cover caption:

Front cover illustration: Confocal micrographs of enteropathogenic Escherichia coli (EPEC)-infected HeLa cells illustrating that the injected Map (Mitochondrial-associated protein) effector molecule induces the formation of cytoskeletal-rich filopodia-like extensions at the site of infection and that this function is independent of its association with mitochondria. In the top panel, Map (green) is delivered into host cells where it associates with the mitochondria immediately below the site of infection (blue; bacterial and nuclear DNA) where dramatic actin-rich filopodia-like extension (red) are also evident. Deletion of Map’s putative mitochondrial targeting sequence results in its accumulation throughout the cytoplasm without inhibiting its ability to induce filopodia formation at the site of infection (bottom panel). Micrographs provided by Dr Mark Jepson, Bristol Cell Imaging Facility. Reproduced with permission [Kenny, B., Ellis, S., Leard, A., Warawa, J., Mellor, H. & Jepson, M. A. (2002). Co-ordinate regulation of distinct host signalling pathways by multifunctional enteropathogenic E. coli (EPEC) effector molecules. Mol Microbiol 44, 1095-1107 (Oxford: Blackwell Science)]. See article by B. Kenny on pp. 1967-1978.